PICK'S DISEASE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        The The gross pathology is consistent nd  distinctive. After stripping  the  leptomeninges, there is seen extreme convolutional atrophy in focal areas extending  posteriorward  from the frontal and the temporal poles (Fig. 1). The posterior third of the superior temporal convolution is characteriscally spared.  The  atrophy  is  typically  bilateral  and symmetrical. One case in the series was unilateral.                                                                                                                                                         In another case (Fig. 2) the coronal section shows circumscribed  atrophy  of  ventrolateral temporal convolutions.  The  abrupt  transiton  from  severe atrophy  to  relatively  normal  appearing  cortex (green arrows)  is essential for the  diagnosis of Pick's disease. As in most cases, there is sparing of the hippocampus (red arrows)  which is often conspicuous as compared  to  the  adjacent atrophied convolutions.